R/data.R
skin.Rd
Original data were collected in the same way as described in Quariter et. al. (2019), and represents cutaneous delivery of econazole nitrate (ECZ in ng/cm^2) on porcine skin from a reference medicinal product and an approved bioequivalent product. The dataset contains 17 pairs of comparable porcine skin samples on which measurement of ECZ deposition was gathered, and log transformed, using both creams.
data(skin)
A `data.frame` with 16 rows and 2 columns:
Econazole nitrate delivery for the reference product.
Econazole nitrate delivery for the generic bioequivalent product.
The observation corresponds to a given skin on which the log ECZ delivery was collected for each of the reference and generic cream.
Quartier, Julie, et al. "Cutaneous Biodistribution: A High-Resolution Methodology to Assess Bioequivalence in Topical Skin Delivery", Pharmaceutics, (2019). Boulaguiem, Younes, et al. "Finite Sample Adjustments for Average Equivalence Testing", Statistics in Medicine, (2023)